In 'Item Remarks Required', the user will select the option as per the requirement.
a. Ask: Select the option if needs to enable Item Remark.
b. Ask on F2: Select the option if needs to ask Item Remark on 'F2' key.
After following the above steps, Item Remark will get enabled which display at the time of creating Sale Bill.
After following the above steps, the Item Remark window will get disabled in at the time of creating sale bill.